An overview into Polyethylene Terephthalate (PET) hydrolases and efforts in tailoring enzymes for improved plastic degradation

Nurul Fatin Syamimi Khairul Anuar and Fahrul Huyop and Ghani Ur-Rehman and Faizuan Abdullah and Yahaya M. Normi and Mohd Khalizan Sabullah and Roswanira Abdul Wahab (2022) An overview into Polyethylene Terephthalate (PET) hydrolases and efforts in tailoring enzymes for improved plastic degradation. International Journal of Molecular Sciences, 23. pp. 1-25.

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Abstract

Plastic or microplastic pollution is a global threat affecting ecosystems, with the current generation reaching as much as 400 metric tons per/year. Soil ecosystems comprising agricultural lands act as microplastics sinks, though the impact could be unexpectedly more far-reaching. This is troubling as most plastic forms, such as polyethylene terephthalate (PET), formed from polymerized terephthalic acid (TPA) and ethylene glycol (EG) monomers, are non-biodegradable environmental pollutants. The current approach to use mechanical, thermal, and chemical-based treatments to reduce PET waste remains cost-prohibitive and could potentially produce toxic secondary pollutants. Thus, better remediation methods must be developed to deal with plastic pollutants in marine and terrestrial environments. Enzymatic treatments could be a plausible avenue to overcome plastic pollutants, given the near-ambient conditions under which enzymes function without the need for chemicals. The discovery of several PET hydrolases, along with further modification of the enzymes, has considerably aided efforts to improve their ability to degrade the ester bond of PET. Hence, this review emphasizes PET-degrading microbial hydrolases and their contribution to alleviating environmental microplastics. Information on the molecular and degradation mechanisms of PET is also highlighted in this review, which might be useful in the future rational engineering of PEThydrolyzing enzymes.

Item Type:	Article
Keyword:	Polyethylene terephthalate, Plastic waste, Biodegradation, Pet Hydrolases, Recycling
Subjects:	S Agriculture > S Agriculture (General) > S1-(972) Agriculture (General) T Technology > TP Chemical technology > TP1-1185 Chemical technology
Department:	FACULTY > Faculty of Science and Natural Resources
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	16 Dec 2024 11:46
Last Modified:	16 Dec 2024 11:46
URI:	https://eprints.ums.edu.my/id/eprint/42292

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