Nur Hanisah Azmi and Norsharina Ismail and Mustapha Umar Imam and Der, Jiun Ooi and Siti Nur Hazwani Oslan (2022) Modulation of high-fat diet-induced brain oxidative stress by Ferulate-rich germinated brown rice ethyl acetate extract. Molecules, 27. pp. 1-20.
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Abstract
The oxidative stress resulting from the production of reactive oxygen species plays a vital role in inflammatory processes and is associated with neurodegenerative changes. In view of the ability of germinated brown rice (GBR) to improve learning and memory, this present study aimed to investigate the mechanistic basis of GBR’s neuroprotection in a high-fat diet (HFD)-induced oxidative changes in adult Sprague–Dawley rats. Ferulate-rich GBR ethyl acetate extract (GBR-EA; 100 mg/kg and 200 mg/kg body weight) was supplemented orally for the last 3 months of 6 months HFD feeding during the study. GBR-EA supplementation was found to improve lipid profile and serum antioxidant status, when compared to the HFD group. Elevated mRNA expressions of SOD1, SOD2, SOD3, Catalase, and GPX were demonstrated in the frontal cortex and hippocampus of GBR-EA treated animals. The pro-inflammatory changes induced by HFD in the hippocampus were attenuated by GBR-EA through the downregulation of CRP and TNF- α and upregulation of PPAR-γ. GBR also reduced the hippocampal mRNA expression and enzyme level of acetylcholinesterase. In conclusion, this study proposed the possible transcriptomic regulation of antioxidant and inflammation in neurodegenerative processes resulting from high cholesterol consumption, with an emphasis on GBR’s potential to ameliorate such changes.
| Item Type: | Article |
|---|---|
| Keyword: | Germinated brown rice, Brain oxidative stress, Inflammation, Acetylcholinesterase, Alzheimer’s disease |
| Subjects: | Q Science > QK Botany > QK1-989 Botany > QK710-899 Plant physiology T Technology > TX Home economics > TX1-1110 Home economics > TX341-641 Nutrition. Foods and food supply |
| Department: | FACULTY > Faculty of Food Science and Nutrition |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 23 Dec 2024 11:14 |
| Last Modified: | 23 Dec 2024 11:14 |
| URI: | https://eprints.ums.edu.my/id/eprint/42368 |
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