Virulence characteristics and emerging therapies for biofilm-forming Acinetobacter Baumannii: a review

Karma G. Dolma and Rachana Khati and Alok K. Paul and Mohammed Rahmatullah and Maria de Lourdes Pereira and Polrat Wilairatana and Bidita Khandelwal and Chamma Gupta and Deepan Gautam and Madhu Gupta and Ramesh K. Goyal and Christophe Wiart and Veeranoot Nissapatorn (2022) Virulence characteristics and emerging therapies for biofilm-forming Acinetobacter Baumannii: a review. Biology, 11. pp. 1-20.

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Abstract

Acinetobacter species is one of the most prevailing nosocomial pathogens with a potent ability to develop antimicrobial resistance. It commonly causes infections where there is a prolonged utilization of medical devices such as CSF shunts, catheters, endotracheal tubes, and similar. There are several strains of Acinetobacter (A) species (spp), among which the majority are pathogenic to humans, but A. baumannii are entirely resistant to several clinically available antibiotics. The crucial mechanism that renders them a multidrug-resistant strain is their potent ability to synthesize biofilms. Biofilms provide ample opportunity for the microorganisms to withstand the harsh environment and further cause chronic infections. Several studies have enumerated multiple physiological and virulence factors responsible for the production and maintenance of biofilms. To further enhance our understanding of this pathogen, in this review, we discuss its taxonomy, pathogenesis, current treatment options, global resistance rates, mechanisms of its resistance against various groups of antimicrobials, and future therapeutics.

Item Type:	Article
Keyword:	Acinetobacter Baumannii, Biofilm, Multidrug-resistance, Microorganisms, Antimicrobial, Therapeutics
Subjects:	Q Science > QH Natural history > QH301-705.5 Biology (General) Q Science > QR Microbiology > QR1-502 Microbiology
Department:	INSTITUTE > Institute for Tropical Biology and Conservation
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	13 Jan 2025 16:19
Last Modified:	13 Jan 2025 16:19
URI:	https://eprints.ums.edu.my/id/eprint/42575

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