Microbial valorization of oil-based substrates for polyhydroxyalkanoates (PHA) production – Current strategies, status, and perspectives

Lim, Sook Wei and Jibrail Kansedo and Tan, Inn Shi and Tan, Yie Hua and Jobrun Nandong and Lam, Man Kee and Clarence M. Ongkudon (2023) Microbial valorization of oil-based substrates for polyhydroxyalkanoates (PHA) production – Current strategies, status, and perspectives. Process Biochemistry, 130. pp. 715-733. ISSN 1359-5113

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Abstract

With the rising interest in developing polyhydroxyalkanoate (PHA) bioplastics as an auspicious substitute for conventional plastics, the exploitation of low-cost oil substrates for PHA biosynthesis has become popular recently. In view of the paucity of feasibility studies on lipid-based PHA production, this paper aims to provide an overview of the PHA production from diverse lipid-rich sources, covering the PHA production efficiencies using different plausible fermentation strategies and the key influencing factors for oil-based PHA production. Considering the high conversion efficiency (97.5% of the theoretical PHA yield), direct fermentation of oil has shown great promise for PHA industrialization. Plant oils which could achieve a high PHA yield (0.25–0.77 g/g) are better carbon sources than waste cooking oil (0.15–0.28 g/g). In addition to providing information on the potential enhancement tools (i.e., mixed cultures, metabolic engineering, and kinetic studies) for lipid-based PHA production, this paper also reviews the techno-economic and life cycle assessment of PHA production in comparison to the conventional plastics. Besides, technical challenges and future perspectives for the commercialization of oil-based PHA production have been discussed (specifically targeting on the concerns of inconsistent production efficiency, complex recovery process, and high production cost), offering further insights towards developing a sustainable circular economy.

Item Type:	Article
Keyword:	Polyhydroxyalkanoates, Biodegradable plastics, Lipid-rich oil, Fermentation strategy, Kinetic studies
Subjects:	T Technology > TD Environmental technology. Sanitary engineering > TD1-1066 Environmental technology. Sanitary engineering > TD194-195 Environmental effects of industries and plants T Technology > TP Chemical technology > TP1-1185 Chemical technology > TP1080-1185 Polymers and polymer manufacture
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	11 Jun 2025 14:55
Last Modified:	11 Jun 2025 14:55
URI:	https://eprints.ums.edu.my/id/eprint/44070

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